Surface immunological markers in acute myeloblastic leukaemia

Cell markers in the recognition of acute myeloblastic leukaemia subtypes.

The diagnosis of acute myeloblastic leukaemia (AML) is based on cell morphology, cytogenetic and molecular changes, cell markers and clinical data. Our aim was to establish whether morphology and cell markers are comparable in the evaluation of AML. Bone marrow smears were analysed, and flow cytometry and monoclonal antibodies were used to determine cell type and maturity. Morphology and cell m...

Acute Myeloblastic Leukaemia

Myeloblastic leukaemia (A.M.L.) and its closely related cytological variants are less responsive to chemotherapy than acute lymphoblastic leukaemia (A.L.L.). A considerable problem still exists with remission induction; a high proportion of patients fail to achieve complete remission, especially among older adults with the disease. The contribution of maintenance chemotherapy after remission is...

Clonogenic cells in acute myeloblastic leukaemia.

N ORMAL granulocytes, monocytes, and erythrocytes are derived from small numbers of bone marrow progenitor cells that have extensive proliferative capacity. 3 In vitro cell culture techniques to identify progenitor cells have been available for 20 years and depend on the ability of these cells to form colonies of fully differentiated cells in semisolid medium in response to specific growth fact...

Association between acute myeloblastic leukaemia and sarcoidosis.

INTRODUCTION Sarcoidosis is a systemic granulomatous disorder thought to be an exaggerated immune response to unknown antigens. It often presents with bilateral mediastinal lymphadenopathy and/or pulmonary infiltrates (1). Sarcoidosis has been found in association with a variety of malignancies, including malignant myeloproliferative disorders (2). To date, only two cases of acute myeloblastic ...

Acute myeloblastic leukaemia presenting with erythema nodosum.